Stanford V

 ( Chemotherapy Regimens Used In Lymphoma ) 

Stanford V (usually spoken as Stanford Five), is a chemotherapy regimen (with accompanying radiation therapy) intended as a first-line treatment for Hodgkin lymphoma. The regimen was developed in 1988, with the objective of maintaining a high remission rate while reducing the incidence of acute and long term toxicity, pulmonary damage, and sterility observed in alternative treatment regimens such as ABVD. The chemical agents used are:

• A Nitrogen mustard such as cyclophosphamide, chlormethine or ifosfamide
• Doxorubicin, an anti-tumor antibiotic
• Vinblastine, an alkaloid cell toxin
• Vincristine, another alkaloid cell toxin
• Bleomycin, another anti-tumor antibiotic
• Etoposide, a DNA toxin
• Prednisone, a corticosteroid

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Drug Regimen The chemotherapy part of Stanford V treatment can last anywhere from 8 to 12 weeks, depending on the staging of the disease. In many cases, this is followed by radiation therapy for anywhere from 2 to 6 weeks to the affected areas of the body.

Stanford V is a more rigorously administered form of chemotherapy, with treatments roughly twice as fast as those of other Hodgkin lymphoma treatments. However, in a randomized controlled study, Stanford V was inferior to ABVD. This study has been criticize for not adhering to the proper Stanford V protocol. Specifically, the radiation therapy component following chemotherapy was not properly administered in the Italian study. A retrospective study from the Memorial Sloan-Kettering Cancer Center displayed results similar to the Stanford Cancer Center's own experience. The study concluded that, "Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL."

Days 1 and 15

Days 1 and 15

Day 1

Days 8 and 22

Days 8 and 22

Days 15, 16

Q2D

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External links

• Lymphoma Information Network
• Includes table for schedule

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